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KAM4U10Bactrim DS: sulfamethoxazole + trimethoprim double-strength tablets, an antibiotic for infections a doctor has confirmed; prescription-only.
| Active ingredient | Sulfamethoxazole + Trimethoprim |
|---|---|
| Format | Tablet |
| Legal status | Prescription-only medicine in the EU/EEA |
| Price | From €41.00 (20 pills) · from €1.80 per pill (100 pills) |
| Delivery | 3–5 working days to most EU/EEA countries (2–7 by country) |
| Availability | In stock |
Generic Sulfamethoxazole + Trimethoprim — Bactrim DS. Available in multiple pack sizes.
Price range
Dispatched within one working day of payment
Pack size & pricing
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€2.05 per unit
€41.00
€2.00 per unit
€60.00
€1.90 per unit
€95.00
€1.80 per unit
€180.00
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Sealed manufacturer packs
Sealed manufacturer blisters or sachets with the batch number and expiry date printed, and the patient information leaflet in every box.
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Tracked shipping on every parcel. If a parcel is lost, we investigate with the courier and resolve it with a replacement shipment or another appropriate solution (see our delivery policy).
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What happens after you order
Order & pay — order and payment confirmed by email
We pack — sealed packs, plain outer box
Dispatched within 1 working day of payment — tracking number emailed
Delivered — 3–5 working days to most EU/EEA countries (2–7 by country), nothing on the outside
Bactrim DS: sulfamethoxazole + trimethoprim double-strength tablets, an antibiotic for infections a doctor has confirmed; prescription-only.
Part of our Antibiotics range.
Bactrim DS combines two antibiotics — sulfamethoxazole and trimethoprim — in a single double-strength (DS) tablet. The pairing blocks two consecutive steps in bacterial folate production, which is why the combination works against organisms that resist either ingredient alone. Its uses include urinary tract infections, certain respiratory and skin infections, and travellers' diarrhoea when the bacteria are known to be susceptible. It is also a standard choice for people allergic to penicillins, since it belongs to a completely different drug class from Amoxicillin 500mg. Bactrim DS should only be used for a doctor-confirmed bacterial infection — it does nothing against viruses such as colds or flu.
How quickly symptoms ease varies by infection type and severity, and feeling better early is not a reason to stop: courses described in the leaflet typically run several days to two weeks depending on what is being treated, and stopping early lets surviving bacteria regrow — sometimes with resistance. Each dose maintains antibacterial levels for roughly half a day, which is why the leaflet describes twice-daily dosing at evenly spaced intervals. If symptoms have not improved after three days, or worsen at any point, contact a doctor rather than extending the course yourself.
Bactrim DS and amoxicillin are different drug classes for different situations, and the right one depends on the infection and your allergy history. Amoxicillin, available here as Amoxicillin 250mg, Amoxicillin 500mg, Amoxicillin 650mg and Amoxicillin 1000mg, is a penicillin often preferred for ear, throat, dental and chest infections. Bactrim DS is frequently chosen for urinary infections and for penicillin-allergic patients. It is not suitable if you are allergic to sulfa drugs. Because the choice is diagnosis-driven, a doctor or pharmacist should confirm which one fits your infection before you order.
Follow the patient leaflet and your doctor's instructions, and finish the course you were prescribed even once you feel well. The leaflet covers fluid intake during treatment, because the sulfamethoxazole component can crystallise in concentrated urine, and sun exposure, because sulfa antibiotics can increase sun sensitivity. Tell your doctor about all other medicines, particularly blood thinners, methotrexate, diuretics and potassium-affecting drugs, which interact with trimethoprim. Bactrim DS is not appropriate in late pregnancy or with significant kidney disease — check first. Our amoxicillin uses and safety guide covers antibiotic basics that apply here too.
Every box of Bactrim DS we ship is sealed manufacturer stock with the batch number and expiry date printed on the blister and carton, plus the patient information leaflet inside. Orders are dispatched within one working day of payment in plain, unbranded packaging, with tracking on every parcel; standard delivery takes 3–5 working days to most EU and EEA countries (2–7 by country) and is free over €110. Packs start at €41.00 for 20 pills.
Bactrim DS (sulfamethoxazole + trimethoprim) is generally well tolerated, but like every antibiotic it can cause side effects. The most common are nausea, vomiting, loss of appetite, mild diarrhoea and skin rash. Some people notice headache or increased sensitivity to sunlight, so use sun protection during a course. Rare but serious reactions need urgent attention: a spreading blistering rash or peeling skin (possible Stevens-Johnson syndrome), unexplained bruising or bleeding, severe watery or bloody diarrhoea, yellowing of the skin or eyes, or signs of high potassium such as muscle weakness and irregular heartbeat — stop the tablets and seek medical help immediately. Side effects become more likely at higher doses and with longer courses, which is why you should never extend a course on your own.
Do not take Bactrim DS if you are allergic to sulfamethoxazole, trimethoprim or any other sulfonamide (sulfa) medicine — sulfa allergy is common and reactions can be severe. It is also unsuitable for people with serious liver damage, severe kidney impairment that is not being monitored, certain blood disorders such as megaloblastic anaemia caused by folate deficiency, and in late pregnancy or while breastfeeding a newborn. Tell a doctor first if you take warfarin, methotrexate, ACE inhibitors or potassium-sparing diuretics (risk of high potassium), phenytoin, or diabetes medicines like glibenclamide, because Bactrim DS interacts with all of these. Elderly patients and anyone with G6PD deficiency should only use it under medical supervision.
Keep Bactrim DS in its original blister strip, in a cool, dry place below 25°C, away from direct sunlight and bathroom humidity. Do not pop tablets out in advance — the foil protects them from moisture. Always store medicines out of sight and reach of children. To check your pack is genuine: the blister should be fully sealed with no lifted foil, each strip should carry a printed batch number and expiry date that match the outer carton, the box should arrive intact and uncrushed, and a patient information leaflet should be included. If anything looks tampered with, do not take the tablets — contact us first.
Current prices: 20 pills for €41.00 (€2.05 per pill), 30 pills for €60.00 (€2.00 per pill), 50 pills for €95.00 (€1.90 per pill) and 100 pills for €180.00 (€1.80 per pill). Buying 100 pills works out 12% cheaper per pill than the smallest pack. Only order what a prescriber has actually recommended, though — antibiotics should be bought for a defined course, not stockpiled indefinitely.
General information about the active ingredient in Bactrim DS.
See the full Sulfamethoxazole + Trimethoprim guide & all Sulfamethoxazole + Trimethoprim productsSulfamethoxazole with trimethoprim, often called co-trimoxazole (and known by brand names such as Bactrim), is a combination antibiotic that pairs two active ingredients in a fixed ratio. It is prescribed for certain bacterial infections, including some urinary tract infections and particular chest infections, and has an established role in preventing and treating a type of pneumonia (Pneumocystis pneumonia) in vulnerable people. It is effective only against susceptible bacteria, not viruses.
The two ingredients act on the same bacterial pathway at different steps. Bacteria need to make folic acid (folate) to build DNA and multiply. Sulfamethoxazole blocks an early step in folate production, while trimethoprim blocks a later step. By interrupting the pathway at two points, the combination has a stronger effect on susceptible bacteria than either drug alone. Human cells obtain folate from the diet and do not rely on this pathway, allowing the medicine to act more selectively.
Take co-trimoxazole exactly as prescribed and read the patient information leaflet carefully. It comes as tablets and an oral liquid. It is generally recommended to take it with a meal or snack and to drink plenty of fluids during treatment to help protect the kidneys. Take doses at evenly spaced times and complete the full course even if you feel better, to help fully clear the infection and limit antibiotic resistance.
Common (usually mild and temporary):
Stop and seek medical help if you experience:
Store in the original packaging below 25°C, protected from light and moisture, out of the sight and reach of children. Follow any specific shelf-life instructions for the oral liquid. Do not use after the expiry date.
Combining sulfamethoxazole and trimethoprim blocks the same bacterial folate pathway at two separate steps, giving a stronger effect against susceptible bacteria than either ingredient alone.
Drinking adequate fluids helps keep urine flowing and supports the kidneys during treatment. Your doctor or pharmacist can advise how much is appropriate for you.
No. Finish the full course as prescribed, even if symptoms improve, to help clear the infection completely and reduce the risk of antibiotic resistance.
Important: This information is general and not a substitute for medical advice. Always read the patient information leaflet supplied with your medicine and consult a doctor or pharmacist before use — especially if you have existing health conditions or take other medication.
The larger the pack, the lower the price per unit.
Bactrim DS isn't stocked on European high-street pharmacy shelves — it's an imported generic, so buying happens online. Kam4eu ships sealed Bactrim DS from €41.00 (4 pack sizes, lower per-unit price on larger packs) to all 27 EU + 3 EEA countries. Orders dispatch within one working day of payment; standard delivery takes 3–5 working days to most EU/EEA countries (2–7 by country), free over €110.00.
Bactrim DS starts from €41.00. Several pack sizes are available — the larger the pack, the lower the per-unit price. European delivery is free on orders over €110, otherwise €20 standard (3–5 working days to most countries, 2–7 by country).
Orders ship in plain, unbranded packaging from our European fulfilment hub, usually within one working day of payment clearing. Standard delivery reaches all 27 EU + 3 EEA countries in 3–5 working days to most of them (2–7 depending on the country); express (1–2 working days) is also available. For EU orders, VAT and duties are settled at checkout via IOSS, so there are no surprise bills on arrival.
Bactrim DS contains two active ingredients: Sulfamethoxazole and Trimethoprim. Always read the patient information leaflet and consult a doctor or pharmacist before first use.
Choose your method at checkout: secure bank/SEPA transfer or PayPal. You'll receive clear payment confirmation by email, and we dispatch within one working day of payment clearing.
Yes. Every order ships in plain, unbranded outer packaging — nothing on the outside indicates the contents or the pharmacy.
DS stands for double strength. A Bactrim DS tablet contains 800mg sulfamethoxazole and 160mg trimethoprim — twice the amount in a regular-strength Bactrim tablet. This lets many adult regimens work with one tablet per dose instead of two. Confirm with a doctor that the DS strength matches the regimen intended for your infection.
Bactrim DS contains no penicillin, so a penicillin allergy alone does not rule it out; whether it suits you is your doctor's decision. It must not be taken if you are allergic to sulfonamide (sulfa) medicines. If you have any allergy history, mention it to a doctor or pharmacist before starting, and stop immediately if a rash develops.
Trimethoprim-sulfamethoxazole is a long-established treatment for uncomplicated urinary tract infections where local bacteria remain susceptible to it. Resistance rates vary by country, so it is not guaranteed to work everywhere. A doctor can judge whether it suits your case; if symptoms persist beyond two to three days of treatment, seek medical review.
Nausea, loss of appetite, and skin rash are the most frequently reported effects. Any rash deserves attention with sulfa antibiotics: stop the tablets and contact a doctor promptly, because rare but serious skin reactions can begin this way. Increased sun sensitivity is also common — read the full leaflet before your first dose.
Alcohol can add to nausea, dizziness and dehydration during treatment. The package leaflet covers alcohol; ask your doctor or pharmacist how it applies to you.
The package leaflet explains how to take Bactrim DS, including with food and fluids; drinking enough during the course matters because the sulfamethoxazole component can crystallise in concentrated urine. Follow the leaflet and your doctor's instructions.
If your symptoms have not started improving after two to three days of correct dosing, do not simply take more. The bacteria may be resistant to sulfamethoxazole-trimethoprim, or the diagnosis may need reviewing. See a doctor — they may switch you to a different antibiotic class rather than repeating the same course.
Trimethoprim has a half-life of roughly 8–10 hours and sulfamethoxazole about 10 hours in healthy adults, so most of a dose is cleared within two to three days of your last tablet. Clearance is slower if your kidneys are impaired, which is why doses are reduced in kidney disease.
Yes — every blister carries a printed expiry date, typically two to three years from manufacture. Do not use tablets past that date: potency declines and the medicine may not clear your infection, which encourages resistance. Dispose of expired antibiotics at a pharmacy rather than in household waste or down the sink.
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Reviewed by the Kam4eu editorial teamMedicine information reviewed 13 August 2026Next review due 13 August 2027
Sources for the medical information on this page
This page is general product and medicine information, not a prescription or a substitute for medical advice. Always read the patient information leaflet supplied with your medicine, and speak to a doctor or pharmacist before starting Bactrim DS — especially if you take other medicines or have a heart, liver or kidney condition.