Pregabalin

Pregabalin is structurally related to the neurotransmitter GABA but does not act directly on GABA receptors. It binds to a specific subunit (the alpha-2-delta subunit) of voltage-gated calcium channels in the central nervous system. This binding reduces the release of several excitatory neurotransmitters involved in transmitting pain signals, seizure activity and anxiety, which is thought to underlie its effects across these conditions.

Take pregabalin exactly as prescribed and follow the patient information leaflet. It is taken by mouth and the dose is usually increased gradually at the start of treatment so your body can adjust. It can generally be taken with or without food. Do not change your dose or stop taking it on your own — if you wish to stop, your doctor will normally reduce the dose slowly over at least a week, as stopping abruptly can cause withdrawal symptoms.

Common (usually mild and temporary):

• Drowsiness and sleepiness
• Dizziness
• Headache
• Dry mouth
• Weight gain or increased appetite
• Blurred vision

• Do NOT stop pregabalin suddenly — the dose should be reduced gradually under medical guidance to avoid withdrawal symptoms.
• It commonly causes drowsiness and dizziness — do not drive or operate machinery until you know how it affects you.
• Pregabalin has a potential for dependence and misuse and is a controlled drug in many countries; take it only as prescribed and never share it.
• Use caution with alcohol, opioids and other sedating medicines, as the combination can cause dangerous drowsiness and breathing problems.
• Tell your doctor about all medicines you take and any history of kidney problems, mood disorders, substance misuse or breathing difficulties.
• Inform your doctor if you are pregnant, planning pregnancy or breastfeeding, as the risks and benefits need careful consideration.
• Seek urgent medical advice if you experience new or worsening low mood, anxiety or thoughts of self-harm.

Store in the original packaging at room temperature, away from excess heat and moisture, out of the sight and reach of children. Do not use after the expiry date, and return unused medicine to a pharmacy for safe disposal.