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Duratia 90mg
Dapoxetine
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Active ingredient
Dapoxetine
Dapoxetine is a prescription medicine used to treat premature ejaculation (PE) in adult men. It belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs), but unlike SSRIs used for depression it is taken on an as-needed basis shortly before sexual activity rather than every day. It is sometimes prescribed alongside a PDE5 inhibitor where both conditions are present, but only under medical supervision.
Reviewed by the Kam4eu Pharmacy Team on 13 August 2026 · Next review August 2027
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Dapoxetine
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Dapoxetine
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How it works
Dapoxetine works by temporarily increasing the amount of the chemical messenger serotonin available between nerve cells in the brain and spinal cord. Serotonin plays a part in the nerve signalling that controls the ejaculatory reflex. By slowing the reuptake of serotonin, dapoxetine can help delay ejaculation and improve a man's sense of control. Because it is short-acting, it is designed to be used before anticipated sexual activity rather than to build up in the body over time.
How it is taken
Take dapoxetine exactly as advised by your doctor and as described in the patient information leaflet. It is generally swallowed whole with a glass of water a few hours before sexual activity, and is taken only when needed rather than daily. Do not take more than one dose in a 24-hour period. To reduce the chance of feeling faint, do not drink alcohol while taking it and stand up slowly after sitting or lying down.
Side effects
Common (usually mild and temporary):
- Dizziness or light-headedness
- Headache
- Nausea
- Diarrhoea
- Drowsiness or tiredness
- Dry mouth
Stop and seek medical help if you experience:
- Fainting or feeling you are about to faint — sit or lie down at once and seek urgent medical help
- Signs of serotonin syndrome such as agitation, confusion, fast heartbeat, fever, shivering or muscle twitching — get emergency care
- New or worsening thoughts of self-harm, suicide or significant mood changes — seek urgent medical advice
- Seizures (fits) — call emergency services
- Severe allergic reaction such as swelling of the face, lips or throat, or difficulty breathing
Safety & who should not take it
- An SSRI-class medicine: must not be combined with MAOIs, or with other serotonergic medicines such as other antidepressants, lithium, tramadol, migraine triptans or St John's Wort, because of the risk of serotonin syndrome.
- Not suitable for men with certain significant heart conditions, including some types of heart failure, heart-rhythm problems or a history of fainting.
- Avoid alcohol while taking dapoxetine, as it can increase dizziness, drowsiness and the risk of fainting.
- Tell your doctor about all other medicines, including those for erectile dysfunction, fungal or HIV infections and certain blood-pressure medicines.
- Intended for adult men only — not for women, children or the elderly outside a doctor's direction.
- Tell your doctor about any history of depression, anxiety, mania, bipolar disorder, epilepsy, or kidney or liver problems before starting.
- Do not drive or operate machinery until you know how dapoxetine affects you, as it may cause dizziness, drowsiness or fainting.
Storage
Store in the original packaging at room temperature, away from excess heat and moisture and out of the sight and reach of children. Do not use after the expiry date, and return unused medicine to a pharmacy for safe disposal.
Frequently asked questions
Is dapoxetine taken every day?+
No. Unlike SSRIs used for depression, dapoxetine is normally taken only when needed, a few hours before anticipated sexual activity, and not more than once in any 24-hour period. Follow your doctor's instructions and the leaflet.
Can dapoxetine be taken with erectile-dysfunction medicines?+
It is sometimes prescribed together with a PDE5 inhibitor when both premature ejaculation and erectile dysfunction are present, but only under a doctor's supervision because of possible interactions and a higher chance of dizziness or fainting.
Why should I avoid alcohol with dapoxetine?+
Alcohol can add to dapoxetine's effects and increase dizziness, drowsiness and the risk of fainting or injury. It is best avoided while you are taking the medicine.
Important: This information is general and not a substitute for medical advice. Always read the patient information leaflet supplied with your medicine and consult a doctor or pharmacist before use — especially if you have existing health conditions or take other medication.
Dapoxetine health guides
How to last longer in bed: what 264 sexual-medicine experts recommend in 2026
Summary: the 2025–26 European (EAU) and Global Andrology Forum guidelines are unusually clear about premature ejaculation: on-demand dapoxetine is the experts' most-preferred medicine (chosen by 37.9% of 264 specialists from 41 countries), behavioural techniques like stop-start genuinely work, and the best results come from combining both — with dapoxetine+sildenafil combinations recommended when erections are also an issue.
Read guideHow to stop premature ejaculation: what actually works
Summary: premature ejaculation is common and very treatable. The evidence points to a combination — the studied medicine dapoxetine, behavioural techniques (stop-start, squeeze, pelvic-floor training), and reducing performance anxiety. Korean clinical research confirms medicine plus technique works best.
Read guidePremature ejaculation: causes, types and treatment options
Summary: premature ejaculation has both psychological and biological causes and comes in lifelong and acquired forms. Treatment matches the cause — dapoxetine, behavioural techniques, treating any underlying ED, and addressing anxiety. Korean epidemiological research maps its prevalence and risk factors.
Read guideDapoxetine for premature ejaculation: how it works and how to use it
Summary: dapoxetine is the first medicine developed specifically for premature ejaculation — a short-acting SSRI taken 1–3 hours before intimacy that meaningfully increases time to climax. Here's how it works, the dose, side effects, interactions, and how it's combined with sildenafil.
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