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Duratia 90mg
Dapoxetine
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Active ingredient
Dapoxetine
Dapoxetine is a prescription medicine used to treat premature ejaculation (PE) in adult men. It belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs), but unlike SSRIs used for depression it is taken on an as-needed basis shortly before sexual activity rather than every day. It is sometimes prescribed alongside a PDE5 inhibitor where both conditions are present, but only under medical supervision.
Reviewed by the Kam4eu Pharmacy Team on 21 June 2026 · Next review June 2027
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Dapoxetine
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Dapoxetine
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How it works
Dapoxetine works by temporarily increasing the amount of the chemical messenger serotonin available between nerve cells in the brain and spinal cord. Serotonin plays a part in the nerve signalling that controls the ejaculatory reflex. By slowing the reuptake of serotonin, dapoxetine can help delay ejaculation and improve a man's sense of control. Because it is short-acting, it is designed to be used before anticipated sexual activity rather than to build up in the body over time.
How it is taken
Take dapoxetine exactly as advised by your doctor and as described in the patient information leaflet. It is generally swallowed whole with a glass of water a few hours before sexual activity, and is taken only when needed rather than daily. Do not take more than one dose in a 24-hour period. To reduce the chance of feeling faint, do not drink alcohol while taking it and stand up slowly after sitting or lying down.
Side effects
Common (usually mild and temporary):
- Dizziness or light-headedness
- Headache
- Nausea
- Diarrhoea
- Drowsiness or tiredness
- Dry mouth
Stop and seek medical help if you experience:
- Fainting or feeling you are about to faint — sit or lie down at once and seek urgent medical help
- Signs of serotonin syndrome such as agitation, confusion, fast heartbeat, fever, shivering or muscle twitching — get emergency care
- New or worsening thoughts of self-harm, suicide or significant mood changes — seek urgent medical advice
- Seizures (fits) — call emergency services
- Severe allergic reaction such as swelling of the face, lips or throat, or difficulty breathing
Safety & who should not take it
- An SSRI-class medicine: must not be combined with MAOIs, or with other serotonergic medicines such as other antidepressants, lithium, tramadol, migraine triptans or St John's Wort, because of the risk of serotonin syndrome.
- Not suitable for men with certain significant heart conditions, including some types of heart failure, heart-rhythm problems or a history of fainting.
- Avoid alcohol while taking dapoxetine, as it can increase dizziness, drowsiness and the risk of fainting.
- Tell your doctor about all other medicines, including those for erectile dysfunction, fungal or HIV infections and certain blood-pressure medicines.
- Intended for adult men only — not for women, children or the elderly outside a doctor's direction.
- Tell your doctor about any history of depression, anxiety, mania, bipolar disorder, epilepsy, or kidney or liver problems before starting.
- Do not drive or operate machinery until you know how dapoxetine affects you, as it may cause dizziness, drowsiness or fainting.
Storage
Store in the original packaging at room temperature, away from excess heat and moisture and out of the sight and reach of children. Do not use after the expiry date, and return unused medicine to a pharmacy for safe disposal.
Frequently asked questions
Is dapoxetine taken every day?+
No. Unlike SSRIs used for depression, dapoxetine is normally taken only when needed, a few hours before anticipated sexual activity, and not more than once in any 24-hour period. Follow your doctor's instructions and the leaflet.
Can dapoxetine be taken with erectile-dysfunction medicines?+
It is sometimes prescribed together with a PDE5 inhibitor when both premature ejaculation and erectile dysfunction are present, but only under a doctor's supervision because of possible interactions and a higher chance of dizziness or fainting.
Why should I avoid alcohol with dapoxetine?+
Alcohol can add to dapoxetine's effects and increase dizziness, drowsiness and the risk of fainting or injury. It is best avoided while you are taking the medicine.
Important: This information is general and not a substitute for medical advice. Always read the patient information leaflet supplied with your medicine and consult a doctor or pharmacist before use — especially if you have existing health conditions or take other medication.
Dapoxetine health guides
Premature Ejaculation: Causes, Treatment and Practical Tips
An overview of what premature ejaculation is, what causes it, how Dapoxetine works and the behavioural techniques that can help.
Read guideSuper Kamagra: Understanding the Sildenafil and Dapoxetine Combination
An explainer on Super Kamagra, the combination of Sildenafil and Dapoxetine, who it is intended for and how the two ingredients work together.
Read guideSuper P-Force Guide: Sildenafil and Dapoxetine Combined
An overview of Super P-Force, a combination of Sildenafil and Dapoxetine designed to address both erectile dysfunction and premature ejaculation.
Read guideSuper Kamagra vs Kamagra: Understanding the Difference
What sets Super Kamagra apart from standard Kamagra, and why the added ingredient changes the conversation.
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