Avanafil vs Sildenafil: How the Newer Fast-Acting ED Tablet Compares
Summary
Avanafil is a more recent PDE5 inhibitor often chosen for its quick onset — here is how it compares with the long-established sildenafil.
Reviewed by the Kam4eu Pharmacy Team on 16 March 2026 · Next review August 2027
Avanafil and sildenafil are both PDE5 inhibitors used to treat erectile dysfunction (ED). Sildenafil is the original, most recognised option, while avanafil is a newer member of the family that is often valued for how quickly it begins to work. Understanding the practical differences can help you have a more informed conversation with your doctor or pharmacist.
The shared mechanism
Both medicines work the same way: they block the PDE5 enzyme, allowing the blood vessels in the penis to relax so that more blood can flow in during sexual arousal. Neither produces an erection on its own — sexual stimulation is essential for either to work. You can learn more about the condition in our erectile dysfunction explained overview.
Speed of onset
The most talked-about difference is timing.
- Avanafil is designed to act quickly, often within around 15 to 30 minutes, which appeals to people who want less of a wait before intimacy.
- Sildenafil typically takes around 30 to 60 minutes to take effect. A heavy or fatty meal can slow it down further. See our Sildenafil guide for more.
Duration
Both tablets are relatively short-acting compared with tadalafil. Their effect generally lasts a few hours, making them "as-needed" options taken ahead of planned activity rather than continuous treatments. Neither should be taken more than once in 24 hours unless a doctor advises otherwise.
Side effects and tolerability
Because they share a mechanism, both can cause similar side effects:
- Headache
- Facial flushing
- Nasal congestion
- Indigestion
Some people report that the newer molecule feels a little gentler on side effects such as visual changes, but individual responses vary widely. The patient information leaflet is the authoritative source for each product.
Which might suit you?
There is no universal winner. Avanafil's quicker onset can suit people who prefer spontaneity, while sildenafil has a long track record and is very widely available. Factors that matter include:
- How much you value a fast onset.
- How your body tolerates each option.
- Other medicines and health conditions you have.
For a broader look at the whole class, see our erectile dysfunction range.
Safety essentials
- Never combine avanafil or sildenafil with nitrates (for chest pain) or with poppers. This can cause a sudden, dangerous fall in blood pressure.
- Be cautious and seek advice if you take alpha-blockers or other blood-pressure medicines.
- An erection lasting longer than four hours is an emergency — seek urgent medical care.
- Stop and get help if you have chest pain, fainting, or sudden changes in vision or hearing.
Summary
Avanafil and sildenafil are close relatives that improve blood flow during arousal. The headline difference is speed: avanafil tends to act faster, while sildenafil is the established standard. A healthcare professional can help you decide which profile fits your needs.
General information only — not medical advice. Always read the patient information leaflet and consult a doctor or pharmacist before starting any medication.
Frequently asked questions
Is avanafil faster than sildenafil?+
Avanafil is generally designed to act more quickly, often within about 15–30 minutes, whereas sildenafil usually takes around 30–60 minutes. Actual timing varies from person to person and can be affected by food.
How long does avanafil last compared with sildenafil?+
Both are relatively short-acting and typically last a few hours, making them suitable as on-demand options. For a much longer window of action, tadalafil is usually the alternative people consider.
Does food affect avanafil and sildenafil?+
Sildenafil can be slowed by a large or fatty meal, so it is often taken on a lighter stomach. Avanafil is less affected by food, but the leaflet for your specific product gives the definitive guidance.
Can I take avanafil and sildenafil together?+
No. You should never combine two PDE5 inhibitors or take more than one dose within 24 hours. Doing so increases the risk of side effects without added benefit.
Are avanafil and sildenafil safe with blood-pressure medicines?+
They must never be used with nitrates and require caution with alpha-blockers and other blood-pressure treatments. Always tell your doctor about every medicine you take before starting either tablet.
Mentioned in this guide
Shop the treatments covered here
Genuine medicines from the guide above — discreetly delivered across the UK & Europe.
Related treatments
Browse the medicines and conditions related to this guide: